Set for December 6 from Las Vegas, the event features two world titles. Johny Hendricks defends his welterweight title against Robbie Lawler and Anthony Pettis puts his lightweight belt on the line vs. Gilbert Melendez.
Holm (7-0) is coming off an April finish of Juliana Werner that won her the Legacy FC title. She went 32-2-3 as a boxer, winning titles in multiple weight classes.
Pennington (4-4) is coming off a split decision loss to Jessica Andrade in March. She won her Octagon debut over Roxanne Modafferi last year.
Below is the current lineup:
UFC Welterweight Championship
Johny Hendricks (c) vs. Robbie Lawler
UFC Lightweight Championship
Anthony Pettis (c) vs. Gilbert Melendez
Heavyweight: Travis Browne vs. Brendan Schaub
Light Heavyweight: Corey Anderson vs. Gian Villante
Heavyweight: Todd Duffee vs. Anthony Hamilton
Middleweight: Eddie Gordon vs. Josh Samman
Lightweight: Tony Ferguson vs. Abel Trujillo
Female Bantamweight: Holly Holm vs. Raquel Pennington